SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including OmicronSARS-CoV-2 융합 억제 리포펩티드는 오미크론을 포함한 다양한 관심 변종에 대해 높은 효능을 유지합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity Alpha antiviral activity Beta broad-spectrum antiviral broad-spectrum antivirals Cell Cell fusion cell-cell fusion combating COVID-19 pandemic D614G Delta drugs effective vaccine Effective vaccines exhibited FIVE fusion inhibitor Gamma Impact Infection inhibiting inhibitor inhibitors Lambda lipopeptide maintain mutant omicron Omicron variant other variant other variants outbreak pseudovirus pseudovirus pseudovirus infection pseudoviruses reduced S protein S proteins SARS-CoV-2 significantly the S protein therapeutic variant variants variants of concern variants of concern. VoC VOCs wild-type WT virus [DOI] 10.1080/22221751.2022.2098060 PMC 바로가기 [Article Type] Article
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2Article Published on 2022-10-062022-11-16 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome affinity Analysis B.1.617.2 Beta bind binding binding affinity cell entry complex complex structure coronavirus coronavirus Coronaviruses Delta Efficiency equine Equus functional Gamma hACE2 HCoV-NL63 HeLa cells high affinity horse human ACE2 indicated Infection infection assay molecular basis Mutation provide pseudovirus pseudovirus infection RBDs receptor Receptor binding domain receptor binding domain. Receptor-binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 variant significantly increased spike receptor-binding domain the RBD the SARS-CoV-2 the spike protein Transmission zoonotic [DOI] 10.1016/j.str.2022.07.005 PMC 바로가기
SARS-CoV-2 spike protein enhances MAP4K3/GLK-induced ACE2 stability in COVID-19Article Published on 2022-09-072022-10-06 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 ACE2 protein cells contribute correlated COVID-19 COVID-19 cohort Degradation E3 ligase ENhance entry receptor epithelial epithelial cell epithelial cells Exosome Exosomes humanized Infection Live virus lysine MAP4K3/GLK mice overexpression pathogenesis of COVID-19 patients phosphorylated prevented pseudovirus infection residue RNA-sequencing SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike SARS-CoV-2 spike protein secretion Serine serum exosome severity stability the SARS-CoV-2 transported UBR4 UBR4. Vesicle with COVID-19 [DOI] 10.15252/emmm.202215904 PMC 바로가기 [Article Type] Article
Humoral, Cellular and Cytokine Immune Responses Against SARS-CoV-2 Variants in COVID-19 Convalescent and Confirmed Patients With Different Disease Severities다양한 질병 중증도를 가진 COVID-19 회복기 및 확인된 환자의 SARS-CoV-2 변이체에 대한 체액, 세포 및 사이토카인 면역 반응Article Published on 2022-05-172022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ADE Against Alpha alpha and delta variants Alpha variant Anti-RBD IgG cellular Cellular immune response cellular immunity chemokine chemokines Confirmed convalescent convalescent sera correlation COVID-19 Cytokines delta variant Delta variants disease disease severity ELISA ELISPOT evaluate exhibited fold greater humoral Humoral and cellular immune responses humoral immune response Humoral immunity IgG IL-6 immune immune response immune responses Immunity immunoassays individual Inflammatory mediators inflammatory mediators. IP-10 MCP-1 mediators multiplex neutralization potency Neutralizing activity Omicron variant Omicron variants Patient patients performed pseudovirus pseudovirus infection quantified Raji cells RBD-specific IgG response risk SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 variant SARS-CoV-2 variants serum severe disease Significant significantly specific antibodies spike-specific antibodies Spike-specific antibody T cell T cells variant virus was measured [DOI] 10.3389/fcimb.2022.862656 PMC 바로가기 [Article Type] Article
Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategyResearch article Published on 2022-05-172022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, 치료법, 치료제, [키워드] activate acute respiratory syndrome antibiotic applied approach binding can be used cathepsin cathepsin L cleave clinically coronavirus coronavirus disease COVID-19 CTSL cysteine protease Daptomycin deep learning drug Drug discovery drug prediction enzyme expand FDA-approved drug identify Infection inhibit inhibit SARS-CoV-2 inhibitor inhibitory effect live SARS-CoV-2 molecular docking novel molecule other disease Potential predict pseudotype pseudovirus infection robust SARS-CoV-2 significantly small molecule Spike protein suggested therapeutic target these compound Treatment Z-FA-FMK [DOI] 10.1016/j.csbj.2022.05.023 [Article Type] Research article
Synthesis and In Vitro Study of Antiviral Activity of Glycyrrhizin Nicotinate Derivatives against HIV-1 Pseudoviruses and SARS-CoV-2 VirusesHIV-1 슈도바이러스 및 SARS-CoV-2 바이러스에 대한 글리시리진 니코틴산 유도체의 항바이러스 활성 합성 및 시험관 내 연구Article Published on 2022-01-042022-09-10 Journal: Molecules [Category] 치료제, [키워드] activity acylation addition agent antiviral action antiviral activity Antiviral agents broad spectrum Cell Cell culture characteristics of patient characterized clinical complications co-morbidities comparable Compound COVID-19 derivative derivatives drug entry inhibitors exhibited General population Glycyrrhizinic acid higher risk HIV HIV-1 HPLC human immunodeficiency virus type 1 in vitro inhibit SARS-CoV-2 inhibitory activity investigated morbidities MTT nicotinates of glycyrrhizic acid nicotinic acid patients pseudovirus pseudovirus infection pseudoviruses Remdesivir Replication resulting SARS-CoV-2 SARS-CoV-2 replication shown strain subtype suggested synthesis target cell Toxicity Vero E6 Vero E6 cell VERO E6 cells virus entry was tested [DOI] 10.3390/molecules27010295 PMC 바로가기 [Article Type] Article
Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells423 Published on 2021-12-062022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] A549 ACE2 ACE2 receptors acute respiratory syndrome airways angiotensin-converting enzyme 2 APEX2 bind bypasse C-terminal domain Calu-3 calu-3 cells cathepsin B Cell cells cofactor contribute coronavirus coronavirus disease COVID-19 demonstrated ENhance experiment expression facilitate glycoprotein H1299 Host host cell host receptor human lung cells human tissues Infection inhibitor interact Intervention lung membrane membrane fusion MYH9 N-terminal domain overexpression pan-coronavirus pathway promote protease pseudovirus infection reduce reduced S1-NTD S2 subunit SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 S serine 2 Significance significantly subunit suggested target the SARS-CoV-2 TMPRSS2 transmembrane variety viral entry virus virus entry wild type [DOI] 10.1073/pnas.2111011118 PMC 바로가기 [Article Type] 423
In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential새로운 SARS-CoV-2 변이체 감염성과 인간 항체 탈출 가능성의 생체 내 특성화Article Published on 2021-10-192022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway animals antibody antibody isotypes binding coronavirus coronavirus disease Coronavirus disease 2019 correlations COVID-19 E484K Human Human coronavirus immune Immune escape in vitro in vivo in vivo modeling India Infection Interaction K417N L452R Los Angeles Lungs mice N501Y nasopharynx neutralization Neutralizing antibodies neutralizing antibody phenomenon plasma pseudovirus pseudovirus infection pseudovirus. RBD receiving Receptor binding domain Reinfection respiratory respiratory infection SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus South Africa spreads susceptibility titers transferred Transmissibility variant variants virion virions virulence [DOI] 10.1016/j.celrep.2021.109838 PMC 바로가기 [Article Type] Article
Peptide Platform as a Powerful Tool in the Fight against COVID-19Article Published on 2021-08-232022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] abrogate ACE2 acute respiratory syndrome addition analyzed antibodies antibody antigenic site applicability conserved conserved RBD region coronavirus COVID-19 demonstrated Dipeptidyl peptidase 4 docking domain DPP4 drug design enzyme fatality global pandemic in vitro in vivo Infection Logistic mechanism methodology Mutation neutralization potency neutralizing antibody peptide peptide-based peptides promote protein–protein docking pseudovirus infection RBD receptor reduce Region S protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selected sequence spike glycoprotein the S protein therapeutic Vaccine vaccine platform Vaccines virus entry VSVpp.SARS-2S [DOI] 10.3390/v13081667 PMC 바로가기 [Article Type] Article